Detection of five novel CTX-M-type extended spectrum beta-lactamases with one to three CTX-M-14 point mutations in isolates from Hefei, Anhui province, China.

摘要

Following the introduction of expanded spectrum cephalo-sporins into clinical usage, the production of extended-spectrum beta-lactamases (ESBLs) by members of the Enterobacteri-aceae has been documented (5, 6). One of these ESBLs, CTX-M, has become the predominant ESBL type in eastern Asia, South America, and Eastern Europe. And it also exhibits an overall preferential hydrolysis of cefotaxime and ceftriaxone over ceftazidime and a higher susceptibility to tazobactam than to clavulanate (2, 8/9). In our study, we also found the dissemination of CTX-M-14 enzyme in our region. Furthermore, several point mutations were also found in the bla_(CTX-M-14) gene that resulted in amino acid substitution.