Enantiopure succinimide derivatives are key structures in biologically active natural products, pharmaceuticals, and important intermediates in organic synthesis. Compounds containing a chiral pyrrolidine motif, which display activity in many biological systems, can be obtained from succinimide derivatives by simple transformations. However, few methodologies exist concerning the synthesis of chiral succinimide derivatives through catalytic asymmetric reactions.The most well-studied method involves enantioselective cyclo-addition reactions using maleimides as the substrates. Asymmetric catalytic addition of nucleophilic reagents to maleimides has also been reported.
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