Catalytic Asymmetric Addition of Alkyl Enol Ethers to 1,2-Dicarbonyl Compounds: Highly Enantioselective Synthesis of Substituted 3-Alkyl-3-Hydroxyoxindoles

摘要

The catalytic asymmetric ene reaction of carbonyl compounds has attracted much attention because it provides an efficient way to construct versatile and useful building blocks. In contrast to the extensive and fruitful studies on asymmetric ene reactions using α-methyl styrene as a nucleophile, fewer cases have been reported in which enol ethers serve as the nucleophile.