Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

摘要

Nanoparticles have emerged as a promising tool in the biomedical field, in which they serve as delivery carriers of imaging agents or drugs for nanomedicines. After intravenous injection, nanoparticles show higher accumulation in angiogenic disease sites than normal tissues as a result of the enhanced permeability and retention (EPR) effect. To further improve their specificity to disease sites, active targeting strategies have been developed using biological targeting moieties, such as antibodies, aptamers, or peptides, which bind proper receptors on the surface of target cells.