Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds

摘要

Metal-catalyzed cycloadditions of alkenyldiazo reagents are useful tools to access carbo- and heterocycles.These diazo compounds are chemically sensitive toward both Bronsted or Lewis acids. Their reported cycloadditions rely heavily on the formation of metal carbenes to initiate regio- and stereoselective 3+n cycloadditions (n = 2-4) with suitable dipolarophiles. A noncarbene route was postulated for a few copper-catalyzed cycloadditions of these diazo species, but they resulted in complete diazo decomposition.