Total Synthesis of the Triglycosyl Phenolic Glycolipid PGL-tb1 from Mycobacterium tuberculosis

摘要

Mycobacterium tuberculosis (M. tb) is one of the most important pathogens. Despite the availability of antibiotics and a vaccine (BCG), one third of the world's population is infected with M. tb, causing 8 million casualties and 1.5 million deaths yearly. Synergy with HIV and the appearance of M. tb strains that are multi-drug resistant or hypervirulent, poses further threats.