Alkylation of Pyridone Derivatives By Nickel/Lewis Acid Catalysis

摘要

Pyridone derivatives are found in many pharmaceuticals and biologically active natural products (Scheme 1) In addition, they often serve as synthetic precursors for nitrogen-containing six-membered-ring compounds, including substituted pyridines and piperidines. Methods for the efficient synthesis of substituted pyridones have thus attracted the interest of synthetic organic and medicinal chemists. In this regard, the regioselective and direct functionalization of the pyridone core would be a significantly valuable synthetic method for the rapid access to substituted pyridone derivatives.