Intermolecular 2+2+1 Carbonylative Cycloaddition of Aldehydes with Alkynes, and Subsequent Oxidation to gamma-Hydroxybutenolides by a Supported Ruthenium Catalyst

摘要

Intermolecular 2+2+1 carbonylative cycloaddition of aldehydes with alkynes and subsequent oxidation to gamma-hydroxybutenolides is achieved using a supported ruthenium catalyst. A ceria-supported ruthenium catalyst promotes the reaction efficiently, even with an ambient pressure of CO or without external CO, thus giving the corresponding gamma-hydroxybutenolide derivatives in good to high yields. Moreover this catalyst can be reused with no loss of activity.