A Photochromic Agonist of AMPA Receptors

摘要

Optochemical genetics uses small photoswitchable molecules to control neuronal activity. These can be attached covalently or noncovalently to their target proteins, which can be ligand or voltage-gated ion channels as well as G-protein coupled receptors. The integration of the resulting hybrid photoreceptors into excitable cells allows for the control of neural networks with the temporal and spatial precision that only light provides.