Unique α,β- and α,α,β,β-Peptide Foldamers Based on cis-β-Amino-cyclopehtanecarboxylic Acid

摘要

Non-natural oligomers with well-defined three-dimensional structures (foldamers) raise great interest owing to their ability to mimic and expand the world of biopolymers.'11 Their successful application in several fields has been shown, for example as antimicrobial compounds, protein-protein interaction inhibitors, or gelating agents. The most widely studied foldamers are built from β- or γ-amino acids subunits, as well as from their combination with natural α-amino acids, and various types of periodic structures have been already described. With the aim to move from structure to function, foldamers must satisfy at least two criteria: being stable under physiological conditions and bearing functional groups typical of the side chains of proteinogenic amino acids.