To date, a unique spoligotyping profile (absent spacers 3, 9, 16, and 39 to 43) has been considered a canonical feature of a Mycobacterium bovis BCG strain, regardless of its country of use. Here, we report the first case of a clinical BCG strain with an unusual, M. bovis-like spoligotyping profile with additionally deleted spacers 1 and 2.Adverse effects of the BCG vaccination, named "BCG disease," "BCG-itis," or "BCG-osis," include both localized complications and disseminated infection (2). In Russia, the published rate of BCG-associated complications in 2003 was 28.1 per 100,000 newly vaccinated children, while lymphadenitis and cold abscesses were the most frequently registered complications, with 16.7 and 7.3 per 100,000, respectively (1).
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