Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

摘要

Whereas the in vitro existence of G-quadruplex DNA has been thoroughly studied during the past decades,its in vivo relevance is still a matter of controversy.The indirect nature of the provided evidence has led to scepticism about whether G-quadruplex DNA actually forms in cells.To address this issue,chemical,biophysical,and biochemical tools that will detect G-quadruplex structures in cells must be developed.