An Organocatalytic Azide-Aldehyde 3+2 Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

摘要

An organocatalytic azide-aldehyde 3+2 cycloaddition (organo-click) reaction of a variety of enotizable aldehydes is reported. The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates. It constitutes an alternative to the previously known CuAAC, RuAAQ and IrAAC click reactions.