Unique Identification of Supramolecnlar Structures in Amyloid Fibrils by Solid-State NMR Spectroscopy

摘要

In recent years,considerable progress has been made in using solid-state NMR spectroscopy to determine atomic-resolution structures of amyloid fibrils'1"41 associated with serious disorders such as Alzheimer's and Parkinson's diseases,prion diseases,and type 2 diabetes.Although the architecture of fibrils is considered to be a continuous stack of 3-sheet ladders,termed a cross-P structure,there may be significant variations in the supramolecular organization of the peptides within the fibrils.Detailed insight may shed light on the assembly process and inspire design of fibril-binding compounds and inhibitors.