Structure-Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor

摘要

Infectious and parasitic disease is estimated to be the second leading cause of death worldwide and is becoming increasingly problematic owing to the steady rise in drug-resistant pathogens. The increase in resistance has also coincided with decreasing numbers of antibiotics brought to the market for the past few decades. Naturally, it is paramount to global human health that new antibiotics are developed, particularly those with novel modes of action and/or unique chemical structures. Herein we present the discovery of sphaerimicin A, a sulfated hybrid polyketide-nucleoside that can be considered to fit both of these descriptors.