Chiral amines are important building blocks for pharmaceutical and agrochemical applications, and considerable research effort has been put into the development of efficient methods for their synthesis. One method for the asymmetric synthesis of amines is the catalytic reduction of ketimines. Even more attractive though is the direct reductive amination as it combines two steps in one: the formation of intermediate imines from simple starting materials (ketones and amines) and their subsequent hydrogenation.
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