Crystal Structure of MethylornitMne Synthase (PylB): Insights into the Pyrrolysine Biosynthesis

Felix Quitterer; Anja List; Wolfgang Eisenreich

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Crystal Structure of MethylornitMne Synthase (PylB): Insights into the Pyrrolysine Biosynthesis

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Pyrrolysine (4, abbreviated as Pyl or O, Scheme 1) is the 22nd amino acid that is encoded by the natural genetic code. In the archaebacterial family Methanosarcinaceae, its incorporation into three proteins (MtmB, MtbB, and MttB) involved in the methylamine catabolic pathway is specified by the amber stop codon UAG.

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《Angewandte Chemie》 |2012年第6期|1339-1342|共4页
作者
Felix Quitterer; Anja List; Wolfgang Eisenreich;
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作者单位

Center for Integrated Protein Science at the Department Chemie Lehrstuhl fur Biochemie, Technische Universitat Munchen Lichtenbergstrasse 4, 85747 Carching (Germany);

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正文语种英语
中图分类应用化学;
关键词
(2R; 3R)-3-methylornithine; iron-sulfur proteins; Methanosarcina barken; PylB protein; pyrrolysine;

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Crystal Structure of MethylornitMne Synthase (PylB): Insights into the Pyrrolysine Biosynthesis

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