Allylic Substitution versus Suzuki Cross-Coupling: Capitalizing on Chemoselectivity with Bifunctional Substrates

摘要

The greatest challenge in the synthesis of complex molecules has been, and continues to be, chemoselectivity. Highly chemoselective reactions obviate the need for elaborate protecting-group strategies and maximize synthetic efficiency. To achieve high levels of chemoselectivity, chemists are increasingly employing transition-metal catalysts, with palladium being favored. Two of the most important and frequently applied palladium-catalyzed reactions are the Suzuki cross-coupling and the Tsuji-Trost allylic substitu-tion.