Microwave grafted, composite and coprocessed materials: drug delivery applications

摘要

Novel modified pharmaceutical materials with desired functionalities are required for the development of drug delivery systems. Excipients are no more inert ingredients but these are playing crucial roles in modifying physicochemical properties of drugs and for imparting desired functionalities in the delivery system. In this review article, modified materials such as grafted, composite and coprocessed have been discussed along with the updated reported literature on the same. Applications of grafted materials as drug release retardant, mucoadhesive polymer and tablet superdisintegrant have been elaborated. Use of composite materials in the development of transdermal films, hydrogels, mlcrospheres, beads and nanoparticles have been discussed. Methods for the preparation of coprocessed materials along with commercial products of different coprocessed excipients have also been enlisted.