The Mizoroki-Heck reaction is a versatile method used to prepare styrene derivatives from readily available aryl halides and alkenes. A major drawback of this method is the necessary use of an expensive palladium complex as a catalyst. Addition of an aryl radical, which is generated from an aryl halide, to an alkene and subsequent elimination of a hydrogen radical in a similar way to homolytic aromatic substitution is a possible approach for a new pathway leading to Mizoroki-Heck-type reactions. However, attack of aryl radicals to alkenes usually results in an addition reaction but not a substitution reaction. Herein, we report that the substitution reaction of aryl halides with styrene derivatives takes place by just using KOtBu, EtOH, and DMF, possibly through a radical mechanism.
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