Titanium Binolate Catalyzed Aminolysis of meso Aziridines: A Highly Enantioselective and Direct Access to 1,2-Diamines

摘要

The asymmetric ring-opening of meso aziridines has only recently attracted attention within the chemical community and offers an elegant and direct synthesis of chiral, α-functionalized amines.The groups of Jacobsen. Shiba-saki, Antilla, and most recently RajanBabu have developed metal-based as well as organocatalytic processes for the synthesis of 1,2-azido amines and 1,2-cyano amines, which were obtained in excellent yields and enantioselectivities; these compounds constitute valuable synthetic precursors to optically pure 1,2-diamines and β-amino acids, respectively.