Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to ~(18)F-Glycopeptides as Effective Imaging Probes for Positron Emission Tomography

摘要

In the field of molecular imaging, positron emission tomography (PET) has emerged as an imaging modality with excellent sensitivity for in vivo studies. PET labeling is challenging since short-lived positron-emitting isotopes such as ~(18)F and ~(11)C are used as labeling agents. The optimization and efficient application of rapid and reliable labeling strategies are prerequisites for obtaining access to new radiopharmaceuticals for both research and clinical trials.