High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor(-)-OseItamivir by Three 'One-Pot' Operations

摘要

A great deal of attention has been paid both in the scientific literature and the general media to the high potential risk of a worldwide spread of avian H5N1 influenza virus,the death rate of which is over 50 .Indeed,should this virus acquire the ability to become capable of spreading easily and directly from human to human it could very possibly cause a disastrous pandemic.(-)-Oseltamivir phosphate(Tamiflu),a neuraminidase inhibitor used in the treatment of both type A and type B human influenza,is one of the most promising therapeutics,and many nations have plans to stock a significant amount of this compound in case of a possible influenza outbreak.