With the recent progress in polymer science, polymeric micelles (PMs) as drug carrier have gained an increasing interest in cancer therapy. PMs comprise amphiphilic graft/ block copolymers that form self-assembled nanostructured core-shell architectures in an aqueous milieu at or above a concentration called critical micelle concentration (CMC). These self-assembled core-shell architectures are known as PMs. The hydro-phobic core of PMs can accommodate a large variety of hydrophobic drugs at higher concentrations, while the hydrophilic corona protects the payloads from the surrounding environment to decide their biological fate 1. Being small in size, PMs can easily permeate through the leaky vasculature and are subsequently retained there for longer periods of time, thus delivering the payload selectively at the target site, the so-called enhanced permeability and retention effect.
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