FeFe-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine

摘要

Hydrogenases catalyze the reversible reduction of protons to yield molecular hydrogen (H2) and occur in three evolutionary unrelated forms termed the Fe-, FeFe-, and NiFe-hydrogenases. FeFe-hydrogenases all contain a complex active-site cof actor termed the H cluster (1, Scheme 1) that consists of a regular 4Fe4S cluster bridged by a shared cysteine thiolate sulfur atom to a 2Fe subcluster with biologically unique carbon monoxide, cyanide, and dithiolate ligands.