Correction of Errors during Protein Synthesis

摘要

The precise translation of genetic information, coded by nucleic acids, into protein sequence is essential for cell survival. Erroneous polypeptides are usually unable to fold correctly, remain inactive, and are finally degraded in the cell. For the synthesis of a linear chain composed of several hundreds amino acids, translation must proceed with high precision. The error rate of translation in vivo has been estimated to be about one error per 10000 amino acid residues.