Synthesis and screening of galactose-linked nitroimidazoles and triazoles against Mycobacterium tuberculosis.

摘要

A series of galactose-linked nitroimidazoles/triazoles were synthesised and screened against Mycobacterium tuberculosis H(37)Rv. Preliminary results were promising with MIC values in the range 1.56-12.5 mug/mL. Most importantly they are active under aerobic condition under which metronidazole is inactive.