Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.

摘要

Marine macrolides that selectively disrupt cell cycle events continue to occupy a central position as lead compounds in the ongoing search for novel anticancer agents, highlighted by the recent FDA approval of Halaven (eribulin mesylate, a fully synthetic analogue of the halichondrins) for the treatment of advanced breast cancer.