Selective Crossed-Tishchenko Reaction-A Waste-Free Synthesis of Benzyl Esters

摘要

The synthesis of esters is one of the most fundamental transformations in organic chemistry. Whole books have been filled with efficient synthetic methods. Still, not all types of esters can be accessed by effective and atom-economical procedures.The most straightforward synthetic route to esters is the condensation of carboxylic acids with alcohols. However, the inherent difficulty connected to this approach results from the reversibility of the reaction, which makes it necessary to either use an excess of one of the reagents or to add a coupling reagent or drying agent.