Induced-Fit Encapsulation by a 1,3,5-Alternate Calix6arene

摘要

Calixarene-based building blocks are widely used for the elaboration of molecular receptors. Calixarenes are highly flexible, in contrast to other concave macrocyclic compounds such as cyclodextrins, cyclotriveratrylenes, or resorcinar-enes. The control of their conformation is thus crucial for the formation of receptors with well-defined cavities. Among the different oligomers, calix4arenes are the most developed since they are easily constrained in a cone or a 1,3-alternate conformation through the alkylation of their phenolic positions. Both conformations have proven to be powerful scaffolds for the elaboration of various host-guest systems.