Effects of the Stationary Phase and the Solvent on the Stereodynamics of biphep Ligands Quantified by Dynamic Three-Column HPLC

摘要

Understanding the influence of the solvent and the stationary phase on chiral compounds is essential to controlling their stereodynamics. Fluctional biaryls with axial chirality, where the barrier is highly sensitive to the substitution pattern, would be a suitable series of compounds to study these effects. Biaryls provide classical examples of atropisomers arising from restricted rotation about a o bond.