Chemoenzymatic Synthesis and Application of Bicyclo 2.2.2 octadiene Ligands: Increased Efficiency in Rhodium-Catalyzed Asymmetric Conjugate Additions by Electronic Tuning

摘要

Chiral dienes are a new class of highly effective ligands, developed independently by Hayashi and Camera et al., that have shown great promise in the field of asymmetric catalysis for reactions catalysed by rhodium and iridium. A range of synthetically useful transformations have been realized in excellent yield and enantiomeric excess using C1-symmetric and C2-symmetric dienes.