Two-Dimensional Ultraviolet (2DUV) Spectroscopic Tools for Identifying Fibrillation Propensity of Protein Residue Sequences

摘要

More than twenty neurodegenerative diseases are associated with the formation and deposition of amyloid fibrils of misfolded proteins. Various amyloid-forming proteins across diverse systems are known to share common structures and fibril formation kinetics. This suggests the existence of common molecular mechanisms for different amyloid diseases.