Comparative Properties of Insulin-like Growth Factor 1(IGF-1)andGly7D-AlaIGF-l Prepared by Total Chemical Synthesis

摘要

Human insulin-like growth factor 1(IGF-1)is a 70-residue single-chain protein that mediates somatic growth.Inborn mutations in the igf-1 gene are associated with a childhood syndrome of impaired growth,mental retardation,and deafness.Although such mutations are rare,broad interest in IGF-1 has been stimulated by its nonclassical roles in neoplasia and the regulation of metabolism.