Biocatalytic Enantioselective Oxidative C-C Coupling by Aerobic G-H Activation

摘要

Reactions that form carbon-carbon bonds are the basis for organic chemistry, setting up the carbon framework of organic molecules. In particular, the formation of C-C bonds by organo- or metal-catalyzed activation of C-H bonds has recently obtained increased attention. However, to the best of our knowledge, no biocatalytic oxidative C-C bond-forming reaction has yet been exploited for synthetic purposes. To date, biocatalysis only offers a limited number of enzymes for synthetic C-C bond formation, such as aldolases, transketolases and hydroxynitrile lyases, and thiamine diphosphate (ThDP)-dependent enzymes.