Min Li, Zhen-Ming Wu, Hui Yang, and S. Joseph Huang Context: Preeclampsia is associated with elevated levels of pro-inflammatory cytokines, excess decidual macrophages, and dendritic cells. IL-1 beta- or TNF-alpha-stimulated leukocyte-free first trimester decidual cells produced abundant macrophage- and dendritic cell-recruiting chemokines identified in preeclamptic decidua. Objective: The relative potency of IL-1 beta- or TNF-alpha-induced first trimester decidual cell-secreted chemokines in chemoattracting macrophages or dendritic cells and the signaling pathways involved in the expression of these chemokines were evaluated.
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