Pharmacological Properties of 2-Aminobenzimidazole Halides and Imidazo1,2-aBenzimidazole Derivatives

摘要

Halides of 2-aminobenzimidazolium and derivatives of 9-substituted 2-(4-fluorophenyl)imidazo1,2-abenzimidazoles have been studied for ten types of biological activity in vitro. Among the aminobenzimidazolium derivatives, a compound with NHE-1 inhibitory activity has been identified. It has been demonstrated that imidazobenzimidazole derivatives affect the duration of the refractory period of rat atria, platelet aggregation, and hemorheological activity and inhibit the formation of end products of glycation. No DPP-4 inhibitory, antioxidant, kappa-opioid, and 5-HT2A and 5-HT3 antagonistic activities have been found among the studied compounds.