Abstract Biological membrane fluidity enables shape reform upon a functionally complementary encounter between a biomolecule and a synthetic nanoparticle. Nanomedicine uses ligand‐cell surface receptor affinities for nanoparticle targeting. However, due to toxicity concerns, the nature of the nanoparticle–biomembrane interaction needs exploration to realize ligand surface density and receptor–ligand interaction effects on subsequent uptake/other interaction outcomes. In this study, giant unilamellar vesicles (GUVs) were surface‐immobilized with a hCAII model receptor to study nanoparticle–complementary surface ligand interactions. We find interaction strength impacts morphological outcomes, namely, inter‐GUV adhesion, lysis, and GUV swallowing. Nanoparticle size, receptor/ligand surface densities, overall receptor/ligand concentrations and ratios affect the strength of adhesion, and thus the outcome. Interaction energy effects on GUV morphological outcomes offer fundamental insights into the design of abiological materials for interacting with biological materials.
展开▼
