The Impact of Paternal Age on New Mutations and Disease in the Next Generation

摘要

(Abstracted from Fertil Steril 2022;118(6):1001–1012 Previous research has long established a link between genetic disorders and advanced maternal age. Newer research has shown an additional and independent link between advanced paternal age and difficulty conceiving, complications during pregnancy, and increased possibility of many conditions including spontaneous dominant disorders, congenital abnormalities, neurodevelopmental conditions, and malignancies.