Direct Access to alpha-Aminosilanes Enabled by Visible-Light-Mediated Multicomponent Radical Cross-Coupling

摘要

alpha-Aminosilanes are an important class of organic compounds that show biological activity. In this communication, a new approach to alpha-aminosilanes that utilizes photoredox catalysis to enable three-component coupling of organo(tristrimethylsilyl)silanes with feedstock alkylamines and aldehydes is presented. A wide range of highly functionalized alpha-aminosilanes can be obtained in good yields under mild conditions. Both primary amines and secondary amines are compatible with this transformation. Moreover, optically pure alpha-aminosilanes are accessible by using chiral amines. Mechanistic studies indicate that reactions proceed through radical/radical cross-coupling of silyl radicals with alpha-amino alkyl radicals.