Synthesis of ternary core-shell carbon sphere@α-Fe_2O_3@Ag composites and their application for simultaneous voltammetric detection of uric acid, xanthine, and hypoxanthine

摘要

Core-shell carbon sphere (CS)@α-Fe_2O_3@Ag was synthesized via a multistep hydrothermal method. First, the D-glucose hydrothermal process was employed to synthesize micron-size CSs on which α-Fe_2O_3 was grown to obtain the composite sphere of CS@α-Fe_2O_3. Thereafter, Ag~+ was reduced on the surface of the CS@α-Fe_2O_3 sphere using NaBH_4 agent to produce the core-shell CS@α-Fe_2O_3@Ag. Finally, microsphere composite CS@α-Fe_2O_3@Ag was coated on a glassy carbon electrode (GCE) to enhance its electrochemical performance in the simultaneous determination of uric acid (UA), xanthine (XN), and hypoxanthine (HP). Results indicated that the CS@α-Fe_2O_3@Ag-coated GCE exhibited improved voltammetric sensitivity toward UA, XN, and HP compared to bare GCE. The oxidation peak currents of the simultaneous detection of UA, XN, and HP increased linearly in the concentration range of 0.5-8.0 μmol L~(-1). The detection limits of the fabricated electrodes for UA, XN, and HP were ～0.042, 0.089, and 0.048 μmol L~(-1), respectively, being more sensitive than many other modified GCEs. Moreover, the CS@α-Fe_2O_3@Ag-coated GCE exhibited good stability and repeatability. This study opens a new perspective for developing highly efficient electrodes for electrochemical analysis.