Enantioselective alpha-Carbonylative Arylation for Facile Construction of Chiral Spirocyclic beta,beta '-Diketones

摘要

We herein describe the first enantioselective alpha-carbonylative arylation, providing a diverse set of chiral spiro beta,beta '-diketones bearing various ring sizes and functionalities in high yields and good to excellent enantioselectivities. Calculations suggest the transformation proceeds through reductive elimination instead of nucleophilic addition pathway.