首页> 外文期刊>Journal of the International Neuropsychological Society: JINS >Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in AmnesticVersusAphasic Dementia
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Montreal Cognitive Assessment (MoCA) Performance and Domain-Specific Index Scores in AmnesticVersusAphasic Dementia

机译:蒙特利尔认知评估(MOCA)在Amnesticversuphasic痴呆症中的性能和域特异性指数分数

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Objective: The Montreal Cognitive Assessment (MoCA) is a popular and simple-to-administer screening instrument to detect cognitive impairment. The MoCA generates a total score and six domain-specific index scores: (1) Memory, (2) Executive Functioning, (3) Attention, (4) Language, (5) Visuospatial, and (6) Orientation. It is unclear whether these MoCA scores can differentiate between distinct clinical dementia syndromes. This study compared MoCA Index scores between amnestic dementia of the Alzheimer's type (DAT) and primary progressive aphasia (PPA), a language-based dementia. Method: Baseline MoCA data were analyzed from 33 DAT, 37 PPA, and 83 cognitively normal individuals enrolled in the Clinical Core of the Northwestern Alzheimer's Disease Center. A one-way analysis of covariance adjusted for age was used to compare MoCA scores among groups. A logistic regression model was implemented to observe individual likelihood of group affiliation based on MoCA Index scores. Results: The mean MoCA total score was significantly higher in controls compared to both patient groups (p< .001) but did not differ between DAT and PPA groups. However, in accordance with salient clinical features commonly observed in DATversusPPA, Memory and Orientation Index scores were lowest in the DAT group (p< .001), whereas Language and Attention Index scores were lowest in the PPA group (p< .001). Multivariate logistic regression analysis showed that the individual effects of Memory (p= .001), Language (p= .002), and Orientation (p= .025) Indices were significant. Conclusions: MoCA Index scores can help differentiate among distinct cognitive syndromes, suggesting it may be a useful brief screening tool to detect domain-specific cognitive impairment.
机译:目的:蒙特利尔认知评估(MoCA)是一种流行且易于管理的筛查工具,用于检测认知障碍。MoCA生成一个总分和六个特定领域的指数分数:(1)记忆,(2)执行功能,(3)注意力,(4)语言,(5)视觉空间,和(6)方向。目前尚不清楚这些MoCA评分是否能区分不同的临床痴呆综合征。这项研究比较了阿尔茨海默型遗忘性痴呆(DAT)和原发性进行性失语(PPA,一种基于语言的痴呆)之间的MoCA指数得分。方法:对西北阿尔茨海默病中心临床中心登记的33名DAT、37名PPA和83名认知正常个体的基线MoCA数据进行分析。根据年龄调整协方差的单向分析用于比较各组间的MoCA得分。根据MoCA指数得分,采用逻辑回归模型观察个体加入群体的可能性。结果:对照组的平均MoCA总分显著高于两个患者组(p<0.001),但DAT组和PPA组之间没有差异。然而,根据DATversusPPA中常见的显著临床特征,DAT组的记忆和定向指数得分最低(p<0.001),而PPA组的语言和注意力指数得分最低(p<0.001)。多元逻辑回归分析显示,记忆(p=0.001)、语言(p=0.002)和方向(p=0.025)指数的个体效应显著。结论:MoCA指数评分有助于区分不同的认知综合征,提示它可能是检测特定领域认知损害的一个有用的简单筛查工具。

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