Analysis of tetrahydrocannabinol derivative from cannabis‐infused chocolate by QuEChERS‐thin layer chromatography‐desorption electrospray ionization mass spectrometry

Yousefi‐Taemeh Maryam; Ifa Demian R.

摘要

Abstract >Recently in Canada and some states of the United States, marijuana (cannabis) has become fully legalized and regulated, for both medical and recreational purposes. This fact is going to make cannabis products such as edibles even more popular than ever before. Therefore, it is assumed that there will be a high demand for analytical methods, which are accurate and sensitive enough to be used in different forensic and pharmaceutical cannabis–related applications. Cannabis derivatives have an extreme range and number of constituents with possible interactions with one another. Thus, this characteristic leads to their vast and highly complex chemistry, which requires robust analytical tools to be able to precisely and accurately quantify and qualify them. We developed and validated an analytical method using desorption electrospray ionization (DESI)–mass spectrometry (MS) to accurately detect, characterize, and quantify cannabinoids and also offer an easy, cost‐effective, and reliable technique, which can be performed in a short time for infused edibles in complex matrices such as chocolate. We evaluated a quantitative analysis of tetrahydrocannabinol (THC) in cannabis‐infused chocolate with thin‐layer chromatography (TLC)–DESI‐MS and QuEChERS extraction method. Both techniques of TLC and QuEChERS are cost‐effective and can be run in short time. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type=“main”xml:lang=“en”><title type=“main”>abstract>最近，在加拿大和美国的一些州，大麻（大麻）已经完全合法化并受到监管，用于医疗和娱乐目的。这一事实将使食用品等大麻产品比以往任何时候都更受欢迎。因此，假设对分析方法的需求很高，这些方法足够准确和敏感，可用于不同的法医和药物大麻相关应用。大麻衍生物的成分范围和数量极为广泛，彼此之间可能存在相互作用。因此，这一特性导致了它们庞大而高度复杂的化学反应，这就需要强大的分析工具来精确、准确地量化和鉴定它们。我们开发并验证了一种使用解吸电喷雾电离（DESI）-质谱（MS）的分析方法，以准确检测、表征和量化大麻素，并提供了一种简单、经济、可靠的技术，可以在短时间内对复杂基质（如巧克力）中的灌注食品进行检测。我们采用薄层色谱法（TLC）–质谱法和奎奇斯萃取法对大麻巧克力中的四氢大麻酚（THC）进行了定量分析。TLC和QuEChERS两种技术都具有成本效益，可以在短时间内运行 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2019年第10期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yousefi‐Taemeh Maryam&option=202" target="_blank" rel="nofollow">Yousefi‐Taemeh Maryam;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ifa Demian R.&option=202" target="_blank" rel="nofollow">Ifa Demian R.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Centre for Research in Mass Spectrometry Department of ChemistryYork UniversityToronto ON M3J 1P3 Canada;</p> <p>Centre for Research in Mass Spectrometry Department of ChemistryYork UniversityToronto ON M3J 1P3 Canada;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cannabis chocolate&option=203" rel="nofollow">cannabis chocolate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DESI‐MS&option=203" rel="nofollow">DESI‐MS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=THC&option=203" rel="nofollow">THC;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=edible marijuana&option=203" rel="nofollow">edible marijuana;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=edible cannabis&option=203" rel="nofollow">edible cannabis;</a> </p> <div class="translation"> 机译：None; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-journal-traditional-chinese-medicine-english_thesis/0201288939266.html">Comprehensive Metabolic Profiling of Modified Gegen Qinlian Decoction by Ultra-high-Performance Liquid Chromatography-Diode Array Detection-Q-Exactive-Orbitrap-Electrospray Ionization-Mass Spectrometry/Mass Spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xuehong Nöst&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xuehong Nöst,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eva‑Maria Pferschy‑Wenzig&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Eva‑Maria Pferschy‑Wenzig,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xiao‑Tong Yu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xiao‑Tong Yu,</a> <a href="/journal-foreign-14321/" target="_blank" rel="nofollow" class="tuijian_authcolor">世界中医药杂志（英文版） .</a> <span>2021</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-journal-traditional-chinese-medicine-english_thesis/0201246752609.html">Metabolomics Analysis of Health Functions of Physalis Pubescens L. using by Ultra-performance Liquid Chromatography/Electrospray Ionization Quadruple Time-of-Flight Mass Spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hang Chu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hang Chu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hui Sun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hui Sun,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guang-Li Yan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Guang-Li Yan,</a> <a href="/journal-foreign-14321/" target="_blank" rel="nofollow" class="tuijian_authcolor">世界中医药杂志（英文版） .</a> <span>2015</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-journal-traditional-chinese-medicine_thesis/0201262468569.html">Metabolomics Analysis of Health Functions of Physalis Pubescens L. using by Ultra-performance Liquid Chromatography/Electrospray Ionization Quadruple Time-of-Flight Mass Spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hang Chu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hang Chu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hui Sun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hui Sun,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guang-Li Yan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Guang-Li Yan,</a> <a href="/journal-foreign-39230/" target="_blank" rel="nofollow" class="tuijian_authcolor">世界中医药杂志：英文版 .</a> <span>2015</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/070408125565.html">Online coupling of thin layer chromatography with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: synthesis and application of a new material for the identification of carbohydrates by thin layer chromatography/matrix free material enhanced laser desorption/ionization mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qureshi Muhammad Nasimullah&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qureshi Muhammad Nasimullah,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stecher Guenther&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Stecher Guenther,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Huck Christian&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Huck Christian,</a> <a href="/journal-foreign-26627/" target="_blank" rel="nofollow" class="tuijian_authcolor">Rapid Communications in Mass Spectrometry: RCM .</a> <span>2010</span><span>,第18期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：薄层色谱与基质辅助激光解吸/电离飞行时间质谱的在线耦合：薄层色谱/无基体材料增强的激光解吸/电离质谱鉴定碳水化合物的新材料的合成与应用</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_analytical-chemistry_thesis/020411352828.html">Desorption Electrospray Ionization Mass Spectrometry Analysis of Lipids after Two-Dimensional High-Performance Thin-Layer Chromatography Partial Separation</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Giuseppe Paglia Demian R. Ifa Chunping Wu Gaetano Corso and R. Graham Cooks&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Giuseppe Paglia Demian R. Ifa Chunping Wu Gaetano Corso and R. Graham Cooks </a> <a href="/journal-foreign-8807/" target="_blank" rel="nofollow" class="tuijian_authcolor">Analytical Chemistry .</a> <span>2010</span><span>,第5期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：二维高效薄层色谱部分分离后脂质的解吸电喷雾电离质谱分析</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/070408127793.html">Direct analysis of Salvia divinorum leaves for salvinorin A by thin layer chromatography and desorption electrospray ionization multi-stage tandem mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Joseph H. Kennedy&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Joseph H. Kennedy,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Justin M. Wiseman&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Justin M. Wiseman </a> <a href="/journal-foreign-26627/" target="_blank" rel="nofollow" class="tuijian_authcolor">Rapid Communications in Mass Spectrometry: RCM .</a> <span>2010</span><span>,第9期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：薄层色谱-解吸电喷雾电离多级串联质谱法直接分析丹参叶中丹参素A的含量</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-257539_thesis/0705010618895.html">Thin-Layer Chromatography (TLC) Coupled with Electrospray Laser Desorption Ionization (ELDI) Mass Spectrometry for High-Throughput Analysis of Mixture</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jentaie Shiea&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jentaie Shiea,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li-Jay Wu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li-Jay Wu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Min-Zong Huang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Min-Zong Huang </a> <a href="/conference-foreign-257539/" target="_blank" rel="nofollow" class="tuijian_authcolor">American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics .</a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：薄层色谱（TLC）与电喷雾激光解吸电离（ELDI）质谱相连，用于混合物的高通量分析</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/0206150586.html">Liquid chromatography coupled with electrospray-ionization mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method development and applications for the analysis of food and medicinal herbs.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee, Kim Chung.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lee, Kim Chung. </a> <span>2009</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱结合电喷雾电离质谱和基质辅助激光解吸/电离飞行时间质谱方法的发展及在食品和草药分析中的应用。</span> </p> </li> <li> <div> <b>9. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040005946577.html">Desorption electrospray ionization mass spectrometry analysis of lipids after two-dimensional high-performance thin-layer chromatography partial separation</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Giuseppe Paglia&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Giuseppe Paglia,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Demian R. Ifa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Demian R. Ifa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chunping Wu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chunping Wu,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：二维高性能薄层色谱部分分离后解吸电喷雾电离质谱分析脂质脂质分离</span> </p> </li> <li> <div> <b>10. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/0100048013633.html">Rapid analysis of antibiotic-containing mixtures from fermentation broths by using liquid chromatography-electrospray ionization-mass spectrometry and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ackermann Bradley L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ackermann Bradley L.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Regg Brian T.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Regg Brian T.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Colombo Luigi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Colombo Luigi,</a> <span>1996</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱-电喷雾电离质谱和基质辅助激光解吸电离-飞行时间质谱快速分析发酵液中的抗生素混合物</span> </p> </li> <li> <div> <b>11. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/02071440134.html">Liquid Chromatography Electrospray Ionization Mass Spectrometric (LC- ESI-MS) and Desorption Electrospray Ionization Mass Spectrometric (DESI-MS) Identification of Chemical Warfare Agents in Consumer Products.</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=D'Agostino, P. A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">D'Agostino, P. A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext= Chenier, C. L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> Chenier, C. L. </a> <span>2007</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱电喷雾电离质谱（LC-EsI-ms）和解吸电喷雾电离质谱（DEsI-ms）鉴定消费品中的化学战剂。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201293516054.html">Analysis of Cocaine and Crack Cocaine via Thin Layer Chromatography Coupled to Easy Ambient Sonic-Spray Ionization Mass Spectrometry</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bruno D.Sabino&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Bruno D.Sabino</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wanderson Romao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Wanderson Romao</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Morena L.Sodre&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Morena L.Sodre</a> <span> <a href="/journal-cn-56200/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 美国分析化学（英文） </a> </span> <span> . 2011</span><span>,第6期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201292114926.html">Analysis of Urea in Petfood Matrices: Comparison of Spectro-Colorimetric, Enzymatic and Liquid Chromatography Electrospray Ionization High Resolution Mass Spectrometry Methods</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Patrick Pibarot&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Patrick Pibarot</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Serge Pilard&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Serge Pilard</a> <span> <a href="/journal-cn-56200/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 美国分析化学（英文） </a> </span> <span> . 2012</span><span>,第9期</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06130424285930.html">Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry-target for the sample analysis, comprises a matrix-assisted laser desorption/ionization time-of-flight plate, a graphene layer, and a metal layer or silicon layer</a> <b>[P]</b> . <span> 外国专利：  DE102010020933A1 </span> <span> . 2011-09-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于样品分析的基质辅助激光解吸/电离飞行时间质谱目标物，包括基质辅助激光解吸/电离飞行时间板，石墨烯层和金属层或硅层 </span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130417935474.html">Coupling of liquid chromatography with mass spectrometry by liquid sample desorption electrospray ionization (DESI)</a> <b>[P]</b> . <span> 外国专利：  US8648297B2 </span> <span> . 2014-02-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱与质谱联用的液体样品解吸电喷雾电离（DESI） </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130420707980.html">Coupling of Liquid Chromatography with Mass Spectrometry by Liquid Sample Desorption Electrospray Ionization (DESI)</a> <b>[P]</b> . <span> 外国专利：  US2013023005A1 </span> <span> . 2013-01-24</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱与质谱联用的液体样品解吸电喷雾电离（DESI） </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704029325231','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704029325231down" data-source="7," data-out-id="Nd8c0bmr5gJtrLDlfbKRwGyicPhSqVUz5K3LeT6jA4Q5atgN8Rg1bZNLVGL+dZVe," data-f-source-id="7" data-title="Analysis of tetrahydrocannabinol derivative from cannabis‐infused chocolate by QuEChERS‐thin layer chromatography‐desorption electrospray ionization mass spectrometry" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="34906" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Analysis of tetrahydrocannabinol derivative from cannabis‐infused chocolate by QuEChERS‐thin layer chromatography‐desorption electrospray ionization mass spectrometry"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.8"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.8"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.8"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>