Identification and characterization of a spreadable IncI1 plasmid harbouring a bla(CTX-M-15) gene in an Italian human isolate of Salmonella serovar Napoli

摘要

Salmonella enterica subsp. enterica serovar Napoli (S. Napoli) ranks among the top serovars causing human in-fections in Italy, although not common in other European countries. Isolates are generally pan-susceptible or resistant to aminoglycosides only, however data on antimicrobial resistance genes in strains of S. Napoli are limited. Recently an isolate encoding resistance to third generation cephalosporins was reported. This study aimed to characterize plasmid-encoded cephalosporin resistance due to the blaCTX-M-15 gene in a human S. Napoli isolate in Italy, and to investigate plasmid stability over time.