A Study of the Physicochemical Properties of Mechanically Treated Arglabin and Its Mechanocomposites Based on Arabinogalactan

摘要

In recent decades, researchers have increasingly turned to natural compounds and preparations created from them. Biologically active terpenoids, in particular, natural sesquiterpene lactones, are of great interest. One of the rich sources of these compounds is a plant of the genus Artemisia, whose representative is wormwood Artemisia glabella Kar et Kir., growing in Central Kazakhstan. In the study of the chemical composition of wormwood, a new biologically active compound, sesquiterpenic lactone arglabin, with antitumor and radiosensitizing properties has been isolated. The antitumor drug "Arglabin" is used in oncological clinics of the Republic of Kazakhstan, Russian Federation, Uzbekistan, the Republics of Georgia, Belarus, Kyrgyzstan and Tajikistan in the complex therapy of tumors of the breast, lung, liver, etc. The purpose of this work is to study the physicochemical properties of mechanically treated arglabin and its mixture with a larch water-soluble polysaccharide arabinogalactan, obtained by mechanochemical means. According to IR, UV and C-13 NMR spectroscopy, long-term mechanochemical treatment does not lead to a change in the chemical composition of arglabin molecules. All the spectra obtained are identical to the spectra of the initial (not mechanically treated) arglabin. Using X-ray analysis, it was shown that in the mechanocomposites of arglabin with arabinogalactan there is no disordering of the crystal structure of arglabin and its molecular dispersion in the polysaccharide matrix does not occur.