Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis

Maagdenberg Hedy; Oosterom Natanja; Zanen Jolanda; Gemmati Donato; Windsor Rachael E.; Heil Sandra G.; Esperon Patricia; Jabeen Shakila; Ruiz-Arguelles Guillermo J.; Zolk Oliver; Hoerning Susanne; Sleurs Charlotte; Lopez-Lopez Elixabet; Moreno-Galvan Monica; van den Heuvel-Eibrink Marry M.; van der Zee Anke H.; Carleton Bruce C.

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Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis

机译：与甲氨蝶呤诱导的癌症治疗中的遗传变异诱导的粘液炎：系统评价和荟萃分析

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Methotrexate (MTX), an important chemotherapeutic agent, is often accompanied with mucositis. The occurrence and severity are unpredictable and show large interindividual variability. In this study, we review and meta-analyze previously studied genetic variants in relation to MTX-induced mucositis.

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来源
《Critical reviews in oncology/hematology》 |2021年第1期|共12页
作者
Maagdenberg Hedy; Oosterom Natanja; Zanen Jolanda; Gemmati Donato; Windsor Rachael E.; Heil Sandra G.; Esperon Patricia; Jabeen Shakila; Ruiz-Arguelles Guillermo J.; Zolk Oliver; Hoerning Susanne; Sleurs Charlotte; Lopez-Lopez Elixabet; Moreno-Galvan Monica; van den Heuvel-Eibrink Marry M.; van der Zee Anke H.; Carleton Bruce C.;
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作者单位

BC Childrens Hosp Res Inst Vancouver BC Canada;

Princess Maxima Ctr Pediat Oncol Utrecht Netherlands;

Univ British Columbia Fac Med Dept Pediat Div Translat Therapeut Vancouver BC Canada;

Univ Ferrara Ctr Thrombosis &

Hemostasis Dept Translat Med Ferrara Italy;

Univ Coll London Hosp NHS Fdn Trust Children &

Young Peoples Canc Serv London England;

Erasmus MC Univ Med Ctr Rotterdam Dept Clin Chem Rotterdam Netherlands;

Univ Republica Fac Quim Dept Bioquim Clin Lab Biol Mol Montevideo Uruguay;

Akershus Univ Hosp Div Med Dept Clin Mol Biol EpiGen Lorenskog Norway;

Clin Ruiz Puebla Ctr Hematol &

Med Interna Puebla Mexico;

Univ Hosp Inst Pharmacol Nat Prod &

Clin Pharmacol Ulm Germany;

Univ Hosp Children &

Adolescents Dept Pediat Oncol &

Immunol Erlangen Germany;

Katholieke Univ Leuven Dept Pediat Hematooncol Leuven Belgium;

Univ Basque Country UPV EHU Dept Genet Phys Anthropol &

Anim Physiol Fac Med &

Nursing Leioa;

Hosp Infantil Mexico Dr Federico Gomez Dept Hematooncol Mexico City DF Mexico;

Univ Amsterdam Amsterdam Univ Med Ctr Dept Resp Med Amsterdam Netherlands;

BC Childrens Hosp Res Inst Vancouver BC Canada;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Methotrexate; Mucositis; Gastrointestinal toxicity; Pharmacogenomics; Pediatric; Adult; Cancer;

机译：甲氨蝶呤;粘膜炎;胃肠道毒性;药物替补症;儿科;成人;癌症;

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Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis

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