A Highly DNA-Duplex-Stabilizing Metal-Salen Base Pair

摘要

The incorporation of one or multiple metal ions into nucleic acids in a defined fashion is currently of great interest for the development of alternative base pairs and the generation of DNA and RNA with novel catalytic and electronic properties.The general idea regarding catalysis is that the metal ion provides a unique catalytic property,while the nucleic acids surrounding it serve as a chiral ligand amenable to evolutionary optimization.Recently,the groups led by Leumann,Meggers,Schultz,Shionoya,Switzer,and Tor presented metal-coordinating nucleic acids,so-called ligandosides,which are able to hold a metal ion inside the double helix.