Sulfate Recognition by Persistent Crystalline Capsules with Rigidified Hydrogen-Bonding Cavities

摘要

Selectivity is a fundamental property of pervasive importance in chemistry and biology as reflected in phenomena as diverse as membrane transport, catalysis, sensing, adsorption, com-plexation, and crystallization. Although the key principles of complementarity and preorganization governing the binding interactions underlying such phenomena were delineated long ago, truly profound designed selectivity has proven elusive, in part because synthetic molecular architectures are neither maximally complementary for binding target species nor sufficiently rigid. Even if a host molecule possesses a high degree of complementarity for a guest species, with almost no exceptions it can distort its structure or even rearrange its conformation altogether to accommodate competing guests.