Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

摘要

We recently described the ability of a planar-chiral derivative of 4-dimethylaminopyridine (DMAP) 1 to achieve catalytic asymmetric additions of nitrogen and oxygen nucleophiles to ketenes to generate amides and esters [Eq.(1)].